To start a lot of NPO's (nonprofit organizations) do start tracking with Excel, so you're in good company. Excel can track simple data, but it is not a relational database with the maturity and robustness of ebase.
Ebase excels at tracking multiple criteria about donors and constituents. It has some wonderfully useful built-in reports and features, all from the suggestions and real-life usage of other NPO's from several years of live usage to manage their organizations.

The specific label concern you have is handled by ebase in very cool logic setup.
One, ebase looks to see if the record is an individual, an organization/company, or a family record.
If an individual, it places the information on the label in the manner specified by the USPS addressing best practices.
If an organization/company, it looks to see if there's a Primary Organizational Contact, if so, it addresses it to this POC.
If it's a family record, ebase looks to the addressing fields used for family mailings.
So you can see, there's logic built into ebase that far out thinks and performs the abilities of a flat-file data set that Excel is capable of.

To not send to a family record AND the individual record... you can tag a record "Do not contact", or use a log code item, or eliminate address duplicates before generating an address list. Many ways of doing this.

So, grab a copy of ebase and start playing around... read the manuals too. Overall, you'll find ebase a far more intelligent, friendly, and more powerful way of tracking you nonprofit orgs data, people, donations, and more! Every day, some one finds a new use for ebase, because of it's free form data collecting/tagging methods.

Hope this helps -- Tim Leed